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Updated: May 22, 2026

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Epigenetics in human gliomas.

Simone Kreth1, Niklas Thon, Friedrich W Kreth

  • 1Research Group of Molecular Medicine, Department of Anesthesiology, University of Munich (LMU), Germany.

Cancer Letters
|April 26, 2012
PubMed
Summary
This summary is machine-generated.

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Aberrant epigenetic changes in gliomas are crucial for tumor development and treatment. Understanding these epigenetic alterations offers new diagnostic and therapeutic strategies for brain tumors.

Area of Science:

  • Oncology
  • Epigenetics
  • Neuro-oncology

Background:

  • Aberrant epigenetic landscapes are increasingly recognized in tumor genesis, progression, and treatment response.
  • Gliomas, particularly glioblastoma, exhibit distinct patterns of DNA methylation, histone modification, and miRNA expression.
  • These epigenetic alterations are fundamental to understanding the heterogeneity of these brain tumors.

Purpose of the Study:

  • To review the basic principles of epigenetic control in gliomas.
  • To discuss the current and future role of epigenetics in prognostic and predictive models for gliomas.
  • To explore diagnostic and therapeutic opportunities arising from epigenetic research in malignant gliomas.

Main Methods:

  • Review of current literature on glioma epigenetics.
Keywords:
Epigenetic networksGlioblastomaMicroRNAsStereotactic biopsy

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  • Analysis of DNA methylation, histone modification, and miRNA expression patterns.
  • Discussion of epigenetic network interactions and clinical workflow models.

    • Main Results:

    • Epigenetic alterations significantly influence glioma development and patient outcomes.
    • Distinct epigenetic patterns contribute to the heterogeneity of gliomas.
    • Epigenetic research is revealing new diagnostic and therapeutic avenues.

    Conclusions:

    • Epigenetic modifications are central to glioma biology and clinical management.
    • Further research into epigenetic networks can refine prognostic and predictive models.
    • Integrating epigenetic profiling into clinical workflows holds promise for improved patient care in malignant gliomas.