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Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
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Utilizing biologic assimilation of bovine fetal collagen in staged skin grafting

James Neill1, Kenneth James, William Lineaweaver

  • 1Department of Pathology, Crossgates River Oaks Hospital, Brandon, MS, USA.

Annals of Plastic Surgery
|April 26, 2012
PubMed

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...