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Updated: Aug 14, 2026
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Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
T-cell acute lymphoblastic leukemia with t(1;18)(p36;q22)
1Department of Pathology, Loyola University Medical Center, Maywood, IL 60153.
Cancer Genetics and Cytogenetics
|November 1, 1990
Summary
Chromosomal abnormalities, including t(1;18) and del(6), were identified in a child with T-cell acute lymphoblastic leukemia (T-ALL) during relapse. These genetic changes, particularly 1p36 rearrangements, are also observed in adult T-ALL cases.
Area of Science:
- Pediatric Oncology
- Cancer Genetics
- Hematologic Malignancies
Background:
- T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer.
- Relapse in T-ALL often involves complex genetic alterations.
- Understanding chromosomal abnormalities is crucial for prognosis and treatment.
Observation:
- A pediatric patient with T-ALL presented with a first bone marrow relapse.
- Specific chromosomal abnormalities, t(1;18)(p36;q22) and del(6)(q21), were detected at relapse.
Findings:
- The identified chromosomal abnormalities include rearrangements at 1p36 and 6q21.
- The 1p36 chromosomal region rearrangements have been previously documented in adult T-ALL patients.
Implications:
- This case highlights the occurrence of specific chromosomal abnormalities in pediatric T-ALL relapse.
- The findings suggest potential shared genetic mechanisms between pediatric and adult T-ALL.
- Further research into these abnormalities may inform targeted therapies for T-ALL.
