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Updated: May 22, 2026
09:27
Cell Subtype-specific Analysis of Neuronal Membrane Proteasome in Somatosensory Neurons
Published on: October 10, 2025
Bortezomib-induced severe autonomic neuropathy
A Stratogianni1, M Tosch, H Schlemmer
1Department of Neurology and Clinical Neurophysiology, Autonomic Laboratory, HELIOS-Klinikum Wuppertal, University of Witten/Herdecke, Heusnerstr. 40, 42283 Wuppertal, Germany.
Summary
Bortezomib therapy can cause peripheral neuropathy and acute autonomic neuropathy. This case study details autonomic dysfunction, including syncope, in a multiple myeloma patient undergoing treatment.
Area of Science:
- Neurology
- Oncology
- Pharmacology
Background:
- Bortezomib is a proteasome inhibitor used in multiple myeloma treatment.
- Peripheral neuropathy is a recognized adverse effect of bortezomib.
- Autonomic dysfunction is a less common but serious potential side effect.
Observation:
- A 75-year-old patient undergoing bortezomib therapy presented with recurrent syncopal episodes.
- The patient's symptoms suggested acute autonomic neuropathy.
Findings:
- The case highlights the clinical presentation and specific patterns of autonomic nervous system involvement.
- Autonomic neuropathy can manifest as syncope in patients treated with bortezomib.
Implications:
- Increased awareness of autonomic neuropathy is crucial for early diagnosis and management in bortezomib-treated patients.
- This case underscores the importance of monitoring for autonomic dysfunction beyond peripheral neuropathy.
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