Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular prevalence of equine herpesvirus type 1 and equine herpesvirus type 4 in thoroughbred and Arabian horse facilities in Türkiye.

Acta veterinaria Hungarica·2026
Same author

Evaluation of Optical Coherence Tomography-Angiography Findings in Keratoconus Patients Treated With Accelerated Cross-linking Protocol.

Eye & contact lens·2025
Same author

Investigation of histatin-1, histatin-3, and histatin-5 peptide levels in corneal epithelial cells obtained from patients with keratoconus.

European journal of ophthalmology·2025
Same author

Nitrosative Stress, Mitochondrial Peptides, and Ferroptosis Markers in Corneal Epithelial Cells from Keratoconus Patients.

Current eye research·2025
Same author

Analysis of the presence of Beta-hemolytic streptococci and cytological profiles in horse tracheal lavage samples with diverse clinical respiratory symptoms.

BMC veterinary research·2025
Same author

Vascular characteristics of pediatric patients with familial Mediterranean fever: a study of optical coherence tomography angiography findings.

Japanese journal of ophthalmology·2025

Related Experiment Video

Updated: May 22, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Does phacoemulsification under topical anesthesia affect retrobulbar blood flow?

Oguzhan Saygili1, Ahmet Mete, Alper Mete

  • 1Department of Ophtalmology, Gaziantep University Medical School, Gaziantep, Turkey.

Journal of Clinical Ultrasound : JCU
|April 26, 2012
PubMed
Summary

Phacoemulsification surgery using topical anesthesia minimally impacts retrobulbar blood flow. This suggests topical anesthesia is safe for patients with ocular perfusion disorders like glaucoma.

More Related Videos

Intracameral Injection in Rats with Low Risk of Adverse Effects
06:19

Intracameral Injection in Rats with Low Risk of Adverse Effects

Published on: May 31, 2024

Related Experiment Videos

Last Updated: May 22, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Intracameral Injection in Rats with Low Risk of Adverse Effects
06:19

Intracameral Injection in Rats with Low Risk of Adverse Effects

Published on: May 31, 2024

Area of Science:

  • Ophthalmology
  • Vascular Physiology
  • Surgical Anesthesia

Background:

  • Phacoemulsification is a common cataract surgery technique.
  • Topical anesthesia is increasingly used for ophthalmic procedures.
  • Understanding its effect on ocular hemodynamics is crucial for patient safety.

Purpose of the Study:

  • To evaluate the hemodynamic effects of phacoemulsification surgery under topical anesthesia.
  • To assess changes in retrobulbar blood flow parameters.

Main Methods:

  • Prospective study utilizing color Doppler imaging.
  • Measured blood flow velocities and indices in key retrobulbar vessels (central retinal artery and vein, posterior ciliary arteries, ophthalmic artery).
  • Evaluated parameters before and 1 day after surgery.

Main Results:

  • A statistically significant increase in the minimum flow velocity (Vmin) of the central retinal artery was observed (p ≤ 0.05).
  • No other measured hemodynamic variables showed significant alterations post-surgery.
  • Indicates a minor impact on overall retrobulbar hemodynamics.

Conclusions:

  • Phacoemulsification surgery performed with topical anesthesia has a limited effect on retrobulbar hemodynamics.
  • Topical anesthesia appears suitable for patients with pre-existing ocular perfusion disorders, including glaucoma.
  • Supports the safety of topical anesthesia in managing cataract patients with compromised ocular blood flow.