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Mumps associated with nephritis
1Department of Pediatrics, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Abstract:
During an endemic of mumps in 1987, urinalysis was performed in 124 children with the symptoms of mumps during the acute phase of the disease, 36 children (29.0%) with microscopic hematuria and 8 children (6.4%) with proteinuria were studied. In the children with abnormal urinalysis, whose creatinine clearance was within the normal range, an urine culture for mumps virus was also performed. Nine specimens (20.4%) were positive, 8 (88.8%) of them during the first 5 days of illness. Renal biopsy, performed in a girl with persistent hematuria, revealed a mild mesangial proliferative glomerulonephritis with deposition of immunoglobulins A and M, C3, and mumps virus antigen in the glomerulus, suggesting an immune complex deposition. Electron microscopy demonstrated a moderate number of granular electron-dense deposits in the paramesangial regions. The relationship between the development of mumps and the onset of nephritis and the immunofluorescent demonstration of mumps antigen in the glomeruli suggested that the mesangial nephropathy may have developed after the mumps infection. Therefore, in our cases, the clinical course was benign.
Insights
Mumps infection in children can cause kidney issues like hematuria and proteinuria. A study found mumps virus in urine and glomeruli, suggesting a link to mild nephritis.
Area of Science:
- Pediatrics
- Nephrology
- Virology
Background:
- Mumps virus can cause various complications beyond parotitis.
- Urinary abnormalities are sometimes observed in children with mumps.
Purpose of the Study:
- To investigate the incidence of urinary abnormalities during a mumps outbreak.
- To explore the potential link between mumps virus and nephritis in children.
Main Methods:
- Urinalysis was performed on 124 children with mumps symptoms.
- Urine cultures for mumps virus were conducted on children with abnormal urinalysis.
- Renal biopsy was performed on a child with persistent hematuria.
Main Results:
- 29% of children had microscopic hematuria, and 6.4% had proteinuria.
- Mumps virus was detected in 20.4% of urine specimens.
- Renal biopsy revealed immune complex glomerulonephritis with mumps virus antigen in the glomeruli.
Conclusions:
- Mumps virus infection may be associated with the development of mesangial proliferative glomerulonephritis.
- The observed nephritis in mumps cases appears to have a benign clinical course.
- Immune complex deposition involving mumps virus antigen is implicated in post-infectious nephritis.