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Mumps associated with nephritis.

C Y Lin1, W P Chen, H Chiang

  • 1Department of Pediatrics, Veterans General Hospital, Taipei, Taiwan, Republic of China.

Child Nephrology and Urology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Mumps infection in children can cause kidney issues like hematuria and proteinuria. A study found mumps virus in urine and glomeruli, suggesting a link to mild nephritis.

Area of Science:

  • Pediatrics
  • Nephrology
  • Virology

Background:

  • Mumps virus can cause various complications beyond parotitis.
  • Urinary abnormalities are sometimes observed in children with mumps.

Purpose of the Study:

  • To investigate the incidence of urinary abnormalities during a mumps outbreak.
  • To explore the potential link between mumps virus and nephritis in children.

Main Methods:

  • Urinalysis was performed on 124 children with mumps symptoms.
  • Urine cultures for mumps virus were conducted on children with abnormal urinalysis.
  • Renal biopsy was performed on a child with persistent hematuria.

Main Results:

  • 29% of children had microscopic hematuria, and 6.4% had proteinuria.

Related Experiment Videos

  • Mumps virus was detected in 20.4% of urine specimens.
  • Renal biopsy revealed immune complex glomerulonephritis with mumps virus antigen in the glomeruli.

    • Conclusions:

    • Mumps virus infection may be associated with the development of mesangial proliferative glomerulonephritis.
    • The observed nephritis in mumps cases appears to have a benign clinical course.
    • Immune complex deposition involving mumps virus antigen is implicated in post-infectious nephritis.