Congenital nephrotic syndrome associated with Lowe's syndrome

Two cases of the oculo-cerebro-renal syndrome of Lowe are reported, in which the course of the disease was very fast and unusual. Within the first hours after birth the patients developed nephrotic syndrome and died at the age of 45 and 4 days, respectively. Renal tissue obtained by biopsy and at autopsy disclosed pronounced glomerular changes.