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Cardiovascular comorbidities in patients with psoriatic arthritis: a systematic review

Anna Jamnitski1, Deborah Symmons, Mike J L Peters

  • 1Department of Rheumatology, Jan van Breemen Research Institute/READE, Dr Jan van Breemenstraat 2, 1056 AB Amsterdam, The Netherlands.

Annals of the Rheumatic Diseases
|April 26, 2012
PubMed

Insights

Patients with psoriatic arthritis (PsA) face increased cardiovascular risk, similar to rheumatoid arthritis. Managing inflammation and traditional risk factors is crucial for cardiovascular health in PsA patients.

Area of Science:

  • Rheumatology
  • Cardiology
  • Epidemiology

Background:

  • Limited data exists on cardiovascular comorbidity and risk factors in psoriatic arthritis (PsA).
  • Understanding the cardiovascular risk profile in PsA is essential for patient management.

Purpose of the Study:

  • To systematically review and summarize available studies on cardiovascular risk in patients with PsA.
  • To evaluate the cardiovascular risk profile in PsA.

Main Methods:

  • A systematic literature search was conducted across Medline, EMBASE, and the Cochrane library.
  • Searched for English-language articles from January 1966 to April 2011.
  • Excluded review articles, case reports, and studies on psoriasis alone.

Main Results:

  • Twenty-eight articles were included in the review.
  • PsA patients showed increased cardiovascular mortality and morbidity.
  • PsA patients exhibited more prominent cardiovascular risk factors like hypertension, dyslipidemia, and obesity.
  • Inflammation suppression showed a favorable effect on cardiovascular surrogate markers.

Conclusions:

  • PsA is associated with an elevated cardiovascular risk, comparable to rheumatoid arthritis.
  • Similar cardiovascular risk management strategies are needed for both PsA and rheumatoid arthritis.
  • Further research is required to determine the impact of inflammation suppression and traditional risk factor modification on cardiovascular risk reduction in PsA.
Abstract

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