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Halothane anaesthesia does not modify the cardiovascular response to phenylephrine in man.
Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|November 1, 1990
Summary
This study found that one percent halothane anesthesia does not alter the vascular response to phenylephrine (PHE) in humans undergoing surgery. Cardiovascular responses to PHE remained consistent, indicating no attenuation of vasoconstriction.
Area of Science:
- Anesthesiology
- Cardiovascular Pharmacology
- Human Physiology
Background:
- Conflicting animal data exist on halothane's effect on vascular response to alpha-1 adrenergic agonists.
- Human data regarding halothane's impact on phenylephrine response are lacking.
Purpose of the Study:
- To investigate the haemodynamic effects of phenylephrine (PHE) during halothane anesthesia in humans.
- To determine if halothane attenuates the vascular response to PHE in patients undergoing coronary artery bypass surgery.
Main Methods:
- Eight patients undergoing coronary artery bypass surgery were studied.
- Haemodynamic responses to graded phenylephrine infusions were measured before and during 1% halothane anesthesia.
- Cardiovascular variables were assessed at baseline and during anesthesia.
Main Results:
- Halothane anesthesia did not alter the dose-response relationship for phenylephrine.
- No significant changes in cardiovascular variables were observed in response to PHE during halothane anesthesia.
- No arrhythmias or signs of myocardial ischemia were detected.
Conclusions:
- One percent halothane anesthesia does not attenuate phenylephrine-induced vasoconstriction in humans.
- The findings suggest that halothane maintains the vascular responsiveness to alpha-1 adrenergic agonists in a clinical setting.