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Detection techniques for immunoassay and DNA probing applications.

E P Diamandis1

  • 1Department of Clinical Biochemistry, Toronto Western Hospital, Ontario, Canada.

Clinical Biochemistry
|October 1, 1990
PubMed
Summary

This review covers advanced biotechnology detection systems, focusing on highly sensitive immunoassay and DNA probing methods. It highlights amplification strategies and future trends in sensitive detection technologies.

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Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Molecular Biology

Background:

  • Detection systems are crucial in biotechnology for various applications.
  • Immunoassays and DNA probing are key techniques.
  • The demand for higher sensitivity in detection is continuously increasing.

Purpose of the Study:

  • To review major detection systems in biotechnology.
  • To focus on immunoassay and DNA probing applications.
  • To discuss systems with potential for extreme sensitivity.

Main Methods:

  • Review of existing literature on biotechnology detection systems.
  • Focus on immunoassay and DNA probing techniques.
  • Analysis of amplification strategies (chemical, enzymatic, exponential).

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Main Results:

  • Several major detection systems are identified.
  • Immunoassay and DNA probing applications are detailed.
  • Approaches for extreme sensitivity using amplification are illustrated.

Conclusions:

  • Advanced detection systems offer extreme sensitivity.
  • Amplification techniques are key to enhancing detection.
  • Future biotechnology will see continued innovation in sensitive detection.