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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Menopause01:28

Menopause

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Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
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Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

Hormone supplementation during aging: how much and when?

K G Sorwell1, J Garten, L Renner

  • 1Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97006, USA.

Rejuvenation Research
|April 27, 2012
PubMed
Summary
This summary is machine-generated.

Dehydroepiandrosterone (DHEA) supplementation improved recognition memory in female macaques but not spatial memory. A new regimen in males aims to enhance elderly cognitive function by replicating youthful androgen profiles.

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Area of Science:

  • Neuroendocrinology
  • Primate Cognitive Neuroscience
  • Aging Research

Background:

  • Circulating dehydroepiandrosterone (DHEA) levels decline with age in humans and nonhuman primates.
  • This age-related decrease in DHEA is linked to cognitive decline.
  • Previous studies showed mixed results regarding DHEA's cognitive benefits.

Purpose of the Study:

  • To investigate the cognitive effects of dehydroepiandrosterone (DHEA) supplementation in perimenopausal rhesus macaques.
  • To develop and test a more comprehensive hormone replacement strategy in aged male macaques to mimic youthful androgen profiles.
  • To determine if enhanced physiological hormone replacement can improve cognitive function in aging primates.

Main Methods:

  • Administered supplementary dehydroepiandrosterone to perimenopausal rhesus macaques.
  • Assessed cognitive functions, including recognition memory and spatial working memory.
  • Developed a novel hormone supplementation regimen in aged male macaques to replicate 24-hour androgen profiles of younger animals.

Main Results:

  • Dehydroepiandrosterone supplementation led to improvements in recognition memory in perimenopausal macaques.
  • No significant benefits were observed for spatial working memory in the supplemented group.
  • A new regimen was established to more accurately mimic youthful androgen profiles in aged male macaques.

Conclusions:

  • DHEA supplementation may offer specific cognitive benefits, such as enhancing recognition memory.
  • Limitations in previous studies necessitated a refined hormone replacement approach.
  • The new comprehensive hormone replacement paradigm is hypothesized to enhance cognitive function in elderly primates.