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Related Experiment Video

Updated: May 22, 2026

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Aging of budding yeast.

Anund Hallén¹

¹Department of Medical Biochemistry and Microbiology, University of Uppsala, Uppsala, Sweden. anundhallen@swipnet.se

Rejuvenation Research

|April 27, 2012

Summary

Protein aggregation in yeast cells contributes to aging and genomic instability. This accumulation may explain the Lansing effect, where daughter cells age faster when born from older mothers.

Area of Science:

Cellular biology
Aging research
Molecular biology

Background:

Protein aggregation is a hallmark of aging.
The budding yeast Saccharomyces cerevisiae is a model organism for aging studies.
The Lansing effect describes accelerated aging in daughter cells of old mothers.

Purpose of the Study:

To investigate the role of insoluble protein accumulation in yeast cell aging.
To determine if protein aggregation causes the Lansing effect.
To explore the link between protein aggregation and genomic instability in aged yeast.

Main Methods:

Microscopy and biochemical assays to detect protein aggregates.
Longitudinal studies of yeast cell lineages.
Analysis of genomic integrity in aged cells.

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Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

Related Experiment Videos

Last Updated: May 22, 2026

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Measuring Replicative Life Span in the Budding Yeast

Measuring Replicative Life Span in the Budding Yeast

Published on: June 25, 2009

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

Main Results:

Significant accumulation of insoluble, cross-linked proteins was observed in aging yeast cells.
The extent of protein aggregation correlated with the severity of the Lansing effect.
Old yeast cells with high protein aggregation levels exhibited increased genomic instability.

Conclusions:

Insoluble protein accumulation is a key driver of aging in Saccharomyces cerevisiae.
Protein aggregation underlies the Lansing effect and contributes to genomic instability.
Targeting protein aggregation may be a strategy to mitigate cellular aging.