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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

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Related Experiment Video

Updated: May 22, 2026

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

Lean oncology: a new model for oncologists.

Vincenzo Montesarchio, Antonio Maria Grimaldi, Bernard A Fox

    Journal of Translational Medicine
    |April 27, 2012
    PubMed
    Summary

    Lean Oncology applies the Toyota Production System (TPS) principles to cancer care, focusing on streamlining processes and eliminating waste to improve patient-centered treatment. This management philosophy enhances efficiency and resource utilization in oncology settings.

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    Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models

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    Area of Science:

    • Oncology
    • Healthcare Management
    • Process Improvement

    Background:

    • The term Lean originates from the Toyota Production System (TPS), emphasizing efficiency and waste reduction.
    • Lean management is a philosophy focused on maximizing productivity with minimal resources.
    • Lean Oncology applies these principles to cancer care, aiming for process simplification and waste elimination.

    Discussion:

    • Lean Oncology prioritizes patient centrality by optimizing care pathways and treatment routes.
    • It involves identifying and removing inefficiencies in the delivery of cancer care.
    • The methodology seeks to improve the overall patient experience and outcomes.

    Key Insights:

    • The core idea of Lean is to 'do more with less' by eliminating non-value-added activities.
    • Internalizing Lean principles can transform corporate culture towards continuous improvement.
    • Lean Oncology represents a shift towards more efficient and patient-focused cancer treatment.

    Outlook:

    • Further integration of Lean principles in healthcare can lead to significant improvements in operational efficiency.
    • The adoption of Lean Oncology has the potential to enhance the quality and accessibility of cancer care.
    • Future research should explore the long-term impact of Lean methodologies on patient outcomes and healthcare costs.