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Updated: May 22, 2026
Intramyocardial Cell Delivery: Observations in Murine Hearts
Published on: January 24, 2014
Intra coronary freshly isolated bone marrow cells transplantation improve cardiac function in patients with ischemic
Ilkay Bozdag-Turan1, R Goekmen Turan, Sophie Ludovicy
1Department of Internal Medicine, Division of Cardiology, Rostock-University, Ernst Hydemann Str 6, Rostock 18055, Germany.
Insights
Autologous bone marrow cell transplantation (BMCs-Tx) improved cardiac function in ischemic heart disease patients. This safe treatment reduced infarct size and improved ejection fraction within six months.
Area of Science:
- Cardiology
- Regenerative Medicine
- Cell Therapy
Background:
- Ischemic heart disease (IHD) presents a significant challenge in cardiovascular medicine.
- Autologous bone marrow cell transplantation (BMCs-Tx) is an emerging therapeutic strategy for cardiovascular diseases.
Purpose of the Study:
- To evaluate the efficacy of intracoronary autologous freshly isolated BMCs-Tx in improving cardiac function in patients with IHD.
- To assess the safety and impact of BMCs-Tx on infarct size and heart function parameters.
Main Methods:
- A prospective, nonrandomized study involving 12 IHD patients treated with intracoronary BMCs-Tx using a point-of-care system.
- A control group of 12 IHD patients received no cell therapy.
- Cardiac function, including global ejection fraction (EF) and infarct size, was assessed via left ventriculography at 6-month follow-up.
Main Results:
- Intracoronary BMCs-Tx significantly reduced infarct size (p < 0.001) and increased global EF (p = 0.003) and infarct wall movement velocity (p < 0.001) after 6 months compared to controls.
- Treated patients showed significant improvements in New York Heart Association (NYHA) classification and B-type natriuretic peptide (BNP) levels (p < 0.001).
- The control group exhibited no significant changes in these parameters.
Conclusions:
- Intracoronary transplantation of autologous freshly isolated BMCs is a safe procedure for IHD patients.
- This cell therapy approach demonstrates potential for significant improvement in cardiac function and clinical outcomes in IHD patients.
Background:
Autologous bone marrow cell transplantation (BMCs-Tx) is a promising novel option for treatment of cardiovascular disease. In this study we analyzed whether intracoronary autologous freshly isolated BMCs-Tx have beneficial effects on cardiac function in patients with ischemic heart disease (IHD).
Results:
In this prospective nonrandomized study we treated 12 patients with IHD by freshly isolated BMCs-Tx by use of point of care system and compared them with a representative 12 control group without cell therapy. Global ejection fraction (EF) and infarct size area were determined by left ventriculography.Intracoronary transplantation of autologous freshly isolated BMCs led to a significant reduction of infarct size (p < 0.001) and an increase of global EF (p = 0.003) as well as infarct wall movement velocity (p < 0.001) after 6 months follow-up compared to control group. In control group there were no significant differences of global EF, infarct size and infarct wall movement velocity between baseline and 6 months after coronary angiography. Furthermore, we found significant decrease in New York Heart Association (NYHA) as well as significant decrease of B-type natriuretic peptide (BNP) level 6 months after intracoronary cell therapy (p < 0.001), whereas there were no significant differences in control group 6 months after coronary angiography.
Conclusions:
These results demonstrate that intracoronary transplantation of autologous freshly isolated BMCs by use of point of care system is safe and may lead to improvement of cardiac function in patients with IHD.
Registration Number:
ISRCTN54510226.
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