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Gene expression profiling in acute Stanford type B aortic dissection
Lixin Wang1, Lei Yao, Daqiao Guo
1Department of vascular surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Objective:
To compare the gene expression profiles of the aorta specimens between patients with Stanford type B aortic dissection (AD) and controls.
Materials And Methods:
Samples of descending aorta were collected from patients with type B AD (n = 12) and from multiorgan donors as controls (n = 12). Phalanx whole genome microarray was used to analyze differential gene expression.
Results:
Of the 6375 probes validated, 623 genes were found to be differentially expressed between patients with type B AD and controls (fold change ≥2). Gene ontology analysis identified significantly enriched gene groups pertaining to cell-cell adhesion, extracellular matrix, cell-matrix adhesion, cytoskeleton, immune and inflammatory response, and apoptosis.
Conclusion:
Genes encoding components related to integrity and strength of the aortic wall were downregulated, whereas those related to inflammatory response were upregulated in type B AD. The altered patterns of gene expression indicate preexisting structural defects that are probably a consequence of insufficient remodeling of the aortic wall.
