Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 22, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

Gene expression profiling in acute Stanford type B aortic dissection.

Lixin Wang1, Lei Yao, Daqiao Guo

  • 1Department of vascular surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Vascular and Endovascular Surgery
|April 27, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to McDannell et al.: Thermal overprinting does not obscure the tectonic origin of the Great Unconformity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Residual Content Impacts Critical Quality Attributes and Performance of Risperidone Microspheres.

Pharmaceutical research·2026
Same author

Interpretable machine learning-augmented quantitative targeted flavoromics for quality grade prediction of Jiangxiangxing baijiu.

Food research international (Ottawa, Ont.)·2026
Same author

DiffSpkSync: A Muscle Synergy-Guided Spiking Diffusion Model for EMG Signal Generation to Improve Gesture Recognition Performance.

IEEE journal of biomedical and health informatics·2026
Same author

Bridging preclinical science to clinical design in the development of long-acting injectables: IQ Consortium Industry Perspectives.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

DuetGS: Two-Stage Controllable 3D Human Reconstruction From Dual Images.

IEEE transactions on visualization and computer graphics·2026

Gene expression in aortic dissection (AD) reveals downregulated genes for aortic wall integrity and upregulated genes for inflammation. These findings suggest underlying structural defects in type B AD patients.

Area of Science:

  • Cardiovascular Biology
  • Genomics
  • Molecular Medicine

Background:

  • Stanford type B aortic dissection (AD) is a life-threatening condition.
  • Understanding the molecular mechanisms underlying AD is crucial for developing effective treatments.

Purpose of the Study:

  • To compare gene expression profiles in aortic tissue between patients with type B AD and healthy controls.
  • To identify genes and pathways involved in the pathogenesis of type B AD.

Main Methods:

  • Whole genome microarray analysis was performed on descending aorta samples from 12 patients with type B AD and 12 controls.
  • Differential gene expression was analyzed, and gene ontology enrichment analysis was conducted.

Main Results:

More Related Videos

A Minimally Invasive Model of Aortic Stenosis in Swine
06:51

A Minimally Invasive Model of Aortic Stenosis in Swine

Published on: October 20, 2023

Related Experiment Videos

Last Updated: May 22, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

A Minimally Invasive Model of Aortic Stenosis in Swine
06:51

A Minimally Invasive Model of Aortic Stenosis in Swine

Published on: October 20, 2023

  • 623 genes were found to be differentially expressed between type B AD patients and controls (fold change ≥2).
  • Enriched gene groups included those related to cell-cell adhesion, extracellular matrix, cell-matrix adhesion, cytoskeleton, immune/inflammatory response, and apoptosis.
  • Genes associated with aortic wall integrity were downregulated, while inflammatory response genes were upregulated.

    • Conclusions:

    • Altered gene expression patterns in type B AD suggest preexisting structural defects.
    • Insufficient aortic wall remodeling may contribute to the development of AD.
    • Upregulation of inflammatory response genes highlights the role of inflammation in AD pathogenesis.