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Updated: May 22, 2026
Rat Model of Closed-Head Mild Traumatic Injury and its Validation
Published on: September 22, 2023
Closed head injury in rats: histopathological aspects in an experimental weight drop model
Danilo dos Santos Silva1, José Nazareno Pearce de Oliveira Brito, Jerúsia Oliveira Ibiapina
1Faculty of Medicine, UESPI, Piaui, Brazil.
Purpose:
To study histopathological findings due to a model of closed head injury by weight loss in rats.
Methods:
A platform was used to induce closed cranial lesion controlled by weight loss with a known and predefined energy. 25 male Wistar rats (Rattus novergicus albinus) were divided in five equal groups which received different cranial impact energy levels: G1, G2, G3 and G4 with 0.234J, 0.5J, 0.762J and 1J respectively and G5 (Sham). Under the effect of analgesia, the brain of each group was collected and prepared for histopathological analysis by conventional optic microscopy.
Results:
It was observed greater number of injured neurons in animals of group 4, however neuronal death also could be noticed in animals of group 5. Intraparenchymal hemorrhages were more frequent in animals of group 4 and the cytotoxic brain swelling and vascular congestion were more intense in this group
Conclusion:
The histopathological analysis of these findings allowed to observe typical cranial trauma alterations and these keep close relation with impact energy.
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