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Updated: May 22, 2026

Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor
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Polymeric dual-slab waveguide interferometer for biochemical sensing applications.

Meng Wang1, Sanna Uusitalo, Christina Liedert

  • 1Optoelectronics and Measurement Techniques Laboratory, University of Oulu, Oulu, Finland. meng.wang@ee.oulu.fi

Applied Optics
|April 27, 2012
PubMed
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This study presents a polymer waveguide sensor for detecting biomolecules. The device shows high sensitivity for both refractive index changes and surface binding events, crucial for biochemical sensing applications.

Area of Science:

  • Optoelectronics
  • Biochemical Sensing
  • Polymer Photonics

Background:

  • Evanescent field interactions are key for waveguide-based biosensing.
  • Polymer waveguides offer a versatile platform for optical sensing applications.

Purpose of the Study:

  • To demonstrate a polymer-based dual-slab waveguide Young's interferometer for biochemical sensing.
  • To investigate refractive index sensing and biomolecular adsorption using the developed sensor.
  • To evaluate the impact of water absorption on sensor stability.

Main Methods:

  • Fabrication of a polymer-based dual-slab waveguide using spin coating.
  • Utilizing the evanescent field for probing biomolecular binding events.
  • Testing with glucose solutions for refractive index sensing and protein solutions (BSA, IgG) for surface sensing.

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Last Updated: May 22, 2026

Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor
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Published on: August 30, 2012

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
09:35

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Published on: May 1, 2012

Implementation of a Reference Interferometer for Nanodetection
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Main Results:

  • Achieved a detection limit of 10(-5) Refractive Index Units (RIU) for homogeneous sensing.
  • Achieved a detection limit of 4 pg/mm(2) for surface sensing (protein adsorption).
  • Evaluated and discussed the influence of water absorption on measurement stability.

Conclusions:

  • The spin-coated polymer waveguide sensor demonstrates satisfactory sensitivity for homogeneous refractive index sensing.
  • The sensor is effective for monitoring molecular binding events on the waveguide surface.
  • Polymer waveguide interferometers are promising for sensitive biochemical detection.