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Updated: May 22, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Sleep-disordered breathing in children with craniosynostosis
Muslim M Alsaadi1, Shaikh M Iqbal, Essam A Elgamal
1Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia.
Sleep-disordered breathing (SDB) is common in children with non-syndromic craniosynostosis (NSC), similar to syndromic craniosynostosis (SC). Early polysomnography (PSG) is recommended for NSC diagnosis to guide surgical decisions.
Area of Science:
- Pediatric Sleep Medicine
- Craniofacial Surgery
- Genetics
Background:
- Syndromic craniosynostosis (SC) shows high sleep-disordered breathing (SDB) prevalence.
- The SDB risk in non-syndromic craniosynostosis (NSC) is not well-established.
Purpose of the Study:
- To investigate the prevalence of SDB in children with NSC.
- To compare SDB rates between NSC and SC.
Main Methods:
- Prospective polysomnography (PSG) evaluation.
- Included children diagnosed with craniosynostosis without prior PSG.
- Study conducted at a tertiary pediatric medical center.
Main Results:
- SDB was present in 50% of NSC and 75% of SC patients.
- No correlation found between suture involvement and SDB presence.
- 14 children (10 NSC, 4 SC) were evaluated.
Conclusions:
- SDB is highly prevalent in both NSC and SC.
- Diagnostic PSG is crucial for NSC evaluation.
- PSG findings can inform surgical timing and necessity.
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