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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Regulatory long non-coding RNA and its functions.

Yong Huang1, Ning Liu, Jian Ping Wang

  • 1Animal Science and Technology College, He Nan University of Science and Technology, Luoyang City 471003, Henan Province, People's Republic of China.

Journal of Physiology and Biochemistry
|April 27, 2012
PubMed
Summary

Long non-coding RNAs (lncRNAs) are increasingly discovered and play roles in gene regulation and biological processes. Further research is needed to understand the functions of most lncRNAs in health and disease.

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Published on: April 10, 2018

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Area of Science:

  • Genomics
  • Molecular Biology
  • Epigenetics

Background:

  • Genome-wide analyses have identified numerous long non-coding RNAs (lncRNAs).
  • While lncRNAs exhibit biological activities, their specific functions remain largely uncharacterized.
  • Emerging evidence suggests lncRNAs regulate gene expression at multiple levels.

Purpose of the Study:

  • To summarize recent research efforts focused on the functional roles of lncRNAs.
  • To highlight the involvement of lncRNAs in diverse physiological and pathological processes.

Main Methods:

  • Review of recent scientific literature on lncRNA functions.
  • Analysis of studies investigating lncRNA roles in gene regulation (epigenetic, transcriptional, post-transcriptional).

Main Results:

  • lncRNAs are implicated in fundamental cellular processes including development and immunity.
  • lncRNAs play significant roles in oncogenesis and various clinical disease states.
  • lncRNAs can modulate gene expression through epigenetic, transcriptional, and post-transcriptional mechanisms.

Conclusions:

  • lncRNAs are crucial regulators of gene expression with broad biological relevance.
  • Understanding lncRNA functions is essential for advancing knowledge in cell biology, disease mechanisms, and therapeutic strategies.