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Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Catenins

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...

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Related Experiment Video

Updated: May 22, 2026

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Published on: June 17, 2014

β-catenin/TCF-1 pathway in T cell development and differentiation.

Jian Ma¹, Ruiqing Wang, Xianfeng Fang

¹Division of Immunology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on Neuroimmune Pharmacology

|April 27, 2012

Summary

The Wnt/β-catenin/T cell factor (TCF) pathway regulates T cell differentiation in the thymus and periphery. Understanding β-catenin/TCF-1 is crucial for T cell function and treating immune diseases.

Related Experiment Videos

Last Updated: May 22, 2026

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Published on: June 17, 2014

Area of Science:

Immunology
Cell Biology
Molecular Biology

Background:

T cells require two differentiation stages to become effective immune responders.
Thymic differentiation (positive/negative selection) generates self-tolerant T cells.
Peripheral differentiation of naïve T cells into effector subtypes (Th1, Th2, Th17, Treg) occurs upon antigen encounter.

Purpose of the Study:

To review the function of the Wnt/β-catenin/T cell factor (TCF) pathway in T cell differentiation.
To elucidate the role of β-catenin/TCF-1 in both thymic and peripheral T cell development.
To highlight the implications for understanding T cell function and treating immune disorders.

Main Methods:

Review of existing literature on T cell differentiation and Wnt/β-catenin/TCF signaling.
Analysis of the regulatory mechanisms of β-catenin/TCF-1 in thymic and peripheral T cell development.
Synthesis of information regarding the consequences of pathway dysfunction.

Main Results:

The Wnt/β-catenin/TCF pathway is a key regulator of T cell differentiation in both primary (thymus) and secondary (peripheral lymphoid tissues) lymphoid organs.
Dysregulation of this pathway can lead to severe autoimmune diseases, such as experimental autoimmune encephalomyelitis, or immune deficiencies.
β-catenin/TCF-1 plays a critical role throughout T cell maturation and activation.

Conclusions:

The β-catenin/TCF-1 pathway is essential for proper T cell differentiation, impacting immune system competence.
Understanding this pathway offers insights into mechanisms governing T cell function.
Targeting the β-catenin/TCF-1 pathway may provide novel therapeutic strategies for autoimmune and immune diseases.