Related Experiment Video
Updated: May 22, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
[Pathophysiology of complex regional pain syndrome (CRPS) type 1]
Dalila Mrabet1, Chekib Khemiri, Ines Ben Mrad
1Service de Rhumatologie, EPS La Rabta, Tunis.
Background:
If the pathophysiology of complex regional pain syndrome (CRPS) type 1 remains controversial, most authors agree on a combination in varying proportions, a sensitization of peripheral nerves.
Aim:
To describe the state of advances in the physiopathology of complex regional pain syndrome type 1.
Methods:
Bibliographic research and literature review performed by referring to databases (Medline, Science Direct)
Results:
The physiopathology of complex regional pain syndrome type 1 remains still poorly understood and controversial. Several arguments demonstrated both peripheral (inflammation, abnormal sympathetic ...) and central (neurological and cognitive) mechanisms.
Conclusion:
A better knowledge of the physiopathology of complex pain syndrome type 1 is necessary in order to adapt efficient curative therapy or to a better prevention of this syndrome.
Related Concept Videos
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction
Nociception
Acute Inflammation III: Local and Systemic Effects
Acute Pancreatitis II: Pathophysiology
Pain
