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Updated: May 22, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Gamma knife radiosurgery for clinically persistent acromegaly.

Xiaomin Liu1, Hideyuki Kano, Douglas Kondziolka

  • 1Department of Neurological Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh, Suite B-400, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.

Journal of Neuro-Oncology
|April 27, 2012
PubMed
Summary

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Gamma knife radiosurgery (GKRS) effectively treats active pituitary adenomas in acromegaly patients, achieving tumor control and endocrine remission in nearly half. This treatment can reduce the need for long-term medication.

Area of Science:

  • Neurosurgery
  • Endocrinology
  • Oncology

Background:

  • Pituitary adenomas require effective treatment strategies.
  • Acromegaly management aims for tumor control and endocrine remission.
  • Gamma knife radiosurgery (GKRS) is an option for unresected, active pituitary adenomas.

Purpose of the Study:

  • To evaluate the efficacy of GKRS for clinically active pituitary adenomas in acromegaly.
  • To assess tumor growth control and endocrine remission rates post-GKRS.
  • To identify factors associated with successful outcomes and adverse events.

Main Methods:

  • Retrospective analysis of 40 patients with active acromegaly treated with GKRS between 1988-2009.
  • Defined endocrine remission as specific growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels off medication.

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  • Assessed tumor control via imaging and monitored pituitary axis function.

    • Main Results:

    • Endocrine remission achieved in 47.5% of patients; endocrine control in an additional 10%.
    • Tumor control observed in 97.5% of patients, with 27 showing regression.
    • Lower pre-GKRS IGF-1 levels and less cavernous sinus invasion correlated with better remission rates.
    • 40% of patients developed new pituitary axis deficiencies; no new visual dysfunction occurred.

    Conclusions:

    • GKRS is an effective treatment for active acromegaly, particularly in tumors less invasive of the cavernous sinus with lower IGF-1 levels.
    • Nearly half of patients achieved remission, potentially avoiding lifelong medication.
    • GKRS offers significant tumor control and endocrine normalization for select acromegaly patients.