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Updated: May 22, 2026

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Published on: November 5, 2019

A global perspective on sickle cell disease.

Banu Aygun1, Isaac Odame

  • 1St Jude Children's Research Hospital, Memphis, Tennessee, USA.

Pediatric Blood & Cancer
|April 27, 2012
PubMed
Summary

Sickle cell disease (SCD) is a major global health issue, particularly in developing nations. Collaborative international partnerships are crucial for advancing SCD education, research, and interventions to reduce disease burden.

Area of Science:

  • Public Health
  • Global Health
  • Hematology

Background:

  • Sickle cell disease (SCD) represents a significant and growing global health challenge.
  • The disease disproportionately affects populations in sub-Saharan Africa, the Middle East, India, the Caribbean, and Brazil.
  • Progress in managing SCD in these high-burden regions has been notably slow.

Purpose of the Study:

  • To highlight the substantial global burden of sickle cell disease (SCD).
  • To emphasize the need for enhanced international collaboration to address SCD.
  • To advocate for improved SCD management strategies in underserved regions.

Main Methods:

  • This study is a review and synthesis of the current understanding of SCD's global impact.
  • It identifies key regions affected by SCD and the challenges in disease management.

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  • It proposes a framework for international cooperation involving various stakeholders.

    • Main Results:

    • SCD poses a significant public health problem in specific global regions, with slow progress in management.
    • Effective reduction of SCD burden requires sustained North-South and South-South partnerships.
    • Widespread education, targeted research, and cost-effective interventions are essential.

    Conclusions:

    • Addressing the global burden of SCD necessitates collaborative efforts between professionals, funding bodies, governments, and industry.
    • The formation of a global network by SCD professionals signifies a proactive step towards tackling the disease.
    • Implementing evidence-based, cost-effective interventions is critical for improving outcomes in developing countries.