Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Use of Botulinum Toxin Type A in Esophageal Atresia Management: a Randomized, Controlled, Investigator-blinded Feasibility and Exploratory Trial in Piglets.

Scientific reports·2026
Same author

Rat Animal Models for Evaluation of the Effects of Sacral and Peripheral Nerve Stimulation on Bladder Function.

Journal of visualized experiments : JoVE·2026
Same author

Peroneal electric transcutaneous neuromodulation versus solifenacin in the treatment of the overactive bladder wet.

Central European journal of urology·2025
Same author

Analysis of the onset of lower urinary tract symptoms in multiple scleroris patients.

World journal of urology·2025
Same author

Sacral Neuromodulation for Neurogenic Lower Urinary Tract, Bowel and Sexual Dysfunction in Patients With Multiple Sclerosis: A Pilot Trial.

Neurourology and urodynamics·2025
Same author

The mechanism of action of neuromodulation in the treatment of overactive bladder.

Nature reviews. Urology·2024

Related Experiment Video

Updated: May 22, 2026

Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements
10:07

Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements

Published on: January 30, 2018

Urinary bladder function in conscious rat pups: a developmental study.

Katarina Zvarova1, Peter Zvara

  • 1Department of Surgery, University of Vermont, College of Medicine, Burlington, Vermont 05405, USA. kzvarova@uvm.edu

American Journal of Physiology. Renal Physiology
|April 27, 2012
PubMed
Summary
This summary is machine-generated.

Neonatal rats show immature voiding patterns and longer micturition reflexes in the first 10 days. Bladder function matures with age, indicated by increased bladder capacity and compliance in developing rat pups.

More Related Videos

Neurodevelopmental Reflex Testing in Neonatal Rat Pups
09:35

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Published on: April 24, 2017

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Related Experiment Videos

Last Updated: May 22, 2026

Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements
10:07

Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements

Published on: January 30, 2018

Neurodevelopmental Reflex Testing in Neonatal Rat Pups
09:35

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Published on: April 24, 2017

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Area of Science:

  • Urology
  • Developmental Biology
  • Physiology

Background:

  • Anesthesia can affect urodynamic studies in neonatal rats.
  • Understanding bladder function development is crucial for pediatric urology.

Purpose of the Study:

  • To characterize voiding patterns and urodynamic parameters in conscious, developing rat pups.
  • To avoid anesthesia-related confounding effects in cystometry.

Main Methods:

  • Conscious cystometry was performed on rat pups at postnatal days 0, 3, 7, 14, and 21.
  • Intravesical saline instillation and continuous monitoring of bladder activity were used.
  • Analysis included voiding patterns, nonvoiding contractions, infused volume, and pressures.

Main Results:

  • Voiding patterns and micturition reflexes matured with age.
  • Time from stimulation to contraction decreased significantly with age.
  • Micturition pressure, bladder capacity, and bladder compliance increased progressively.
  • Interrupted voiding patterns were observed in pups younger than 10 days.

Conclusions:

  • Conscious cystometry provides reproducible data on neonatal rat bladder function.
  • Immature voiding and prolonged micturition contractions characterize the first 10 postnatal days.
  • The study demonstrates age-related changes in urodynamic parameters during early development.