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Related Concept Videos

Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Structure of Cadherins01:25

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...
Catenins01:23

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...

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Related Experiment Video

Updated: May 22, 2026

Dissection and Culture of Chick Statoacoustic Ganglion and Spinal Cord Explants in Collagen Gels for Neurite Outgrowth Assays
11:08

Dissection and Culture of Chick Statoacoustic Ganglion and Spinal Cord Explants in Collagen Gels for Neurite Outgrowth Assays

Published on: December 20, 2011

Cadherins in brain morphogenesis and wiring.

Shinji Hirano1, Masatoshi Takeichi

  • 1Department of Neurobiology and Anatomy, Kochi Medical School, Okoh-cho Kohasu, Nankoku-City 783–8505, Japan. s-hirano@kochi-u.ac.jp

Physiological Reviews
|April 27, 2012
PubMed
Summary

Cadherins are crucial for cell adhesion and animal development. This review details their vital roles in nervous system development, function, and associated disorders in vertebrate brains.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Cadherins are calcium-dependent cell-cell adhesion molecules essential for animal morphogenesis.
  • Cadherin-related molecules regulate cell adhesion, proliferation, and planar cell polarity.
  • Recent advances highlight the significant roles of these molecules in the nervous system.

Purpose of the Study:

  • To review the functions of cadherins and related molecules in neural development.
  • To discuss the involvement of cadherins in the functioning of the vertebrate brain.
  • To explore the implications of cadherins in neural disorders.

Main Methods:

  • Literature review of studies on cadherins and related molecules.
  • Analysis of research on cadherin function in neural development.

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Wholemount Immunohistochemistry for Revealing Complex Brain Topography
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Wholemount Immunohistochemistry for Revealing Complex Brain Topography

Published on: April 5, 2012

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Last Updated: May 22, 2026

Dissection and Culture of Chick Statoacoustic Ganglion and Spinal Cord Explants in Collagen Gels for Neurite Outgrowth Assays
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Published on: December 20, 2011

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration
09:07

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Published on: March 17, 2014

Wholemount Immunohistochemistry for Revealing Complex Brain Topography
09:23

Wholemount Immunohistochemistry for Revealing Complex Brain Topography

Published on: April 5, 2012

  • Synthesis of findings regarding cadherins in brain function and disorders.

    • Main Results:

    • Cadherins are critical for establishing and maintaining neural architecture during development.
    • These molecules influence neuronal migration, axon guidance, and synapse formation.
    • Dysregulation of cadherins is implicated in various neurological conditions.

    Conclusions:

    • Cadherins and related molecules are indispensable for proper neural development and function.
    • Understanding cadherin roles offers insights into potential therapeutic strategies for neural disorders.
    • Further research is needed to fully elucidate the complex functions of cadherins in the brain.