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Epidermal growth factor receptor mRNA in livers from newborn, adult and partially hepatectomized rats
Y Satoh1, Y Hoshikawa, S Ichii
1Division of Physiology, Tottori University School of Medicine, Yonago, Japan.
Endocrinologia Japonica
|June 1, 1990
Abstract:
Epidermal growth factor (EGF) receptor mRNA expression in livers of newborn, adult control and partially hepatectomized rats 1 and 3 days post-operation was examined by Northern blot analysis. A human EGF receptor cDNA (P 64-1, Ullrich et al., 1984) was hybridized to RNA species of 10, 6 and 3 kb. These mRNAs were profoundly decreased in livers from newborn rats and relatively decreased in regenerating rat livers. beta-Actin mRNA in these tissues showed a tendency to increase over that of the adult controls.