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Updated: May 22, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Visualization of chronic myocardial infarction using the intravascular contrast agent MS-325 (gadofosveset) in
Thomas Thouet1, Bernhard Schnackenburg, Thomas Kokocinski
1Department of Internal Medicine/Cardiology, German Heart Institute Berlin, 13353 Berlin, Germany.
Aims:
The aim of this study was to evaluate the potential of visualizing chronic myocardial infarction in patients using the intravascular CA MS-325 (gadofosveset, EPIX Pharmaceuticals, Mass, USA).
Methods:
Nine patients were enrolled in a clinical phase II multicenter trial for MRCA and perfusion imaging using MS-325. They had objective evidence of chronic myocardial infarction as visualized by previously performed late gadolinium (Gd) enhancement imaging (LGE) with a conventional extracellular Gd-DTPA CA (Magnevist, Bayer Healthcare, Germany, 0.2 mmol/kg/body weight) serving as reference standard. A prepulse-optimized LGE study was performed immediately and at several time points after injection of MS-325 (0.05 mmol/kg/body weight). The number and localization of segments demonstrating LGE with MS-325 as well as signal intensities were compared with the reference standard (Gd-DTPA).
Results:
Using MS-325, LGE could be detected at every time point in all 9 patients. The accuracy of LGE with MS-325 as compared to LGE with Gd-DTPA was highest 54 ± 4 minutes after contrast injection, resulting in a sensitivity of 84% with a specificity of 98%.
Conclusion:
The intravascular CA MS-325 has the potential to visualize chronic myocardial infarction. However, in comparison with Gd-DTPA, the transmural extent and the number of segments are smaller.
Insights
The intravascular contrast agent MS-325 shows potential for visualizing chronic myocardial infarction. While effective, it detected a smaller extent of infarction compared to the standard Gd-DTPA contrast agent.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Medical Diagnostics
Background:
- Chronic myocardial infarction (MI) diagnosis relies on imaging techniques.
- Late gadolinium enhancement (LGE) using conventional contrast agents (CAs) is the reference standard.
- Novel intravascular CAs are being explored for improved visualization.
Purpose of the Study:
- To evaluate the efficacy of the intravascular CA MS-325 for visualizing chronic MI.
- To compare MS-325 with a standard extracellular CA (Gd-DTPA) in LGE imaging.
Main Methods:
- A phase II clinical trial involving 9 patients with confirmed chronic MI.
- Magnetic Resonance Angiography (MRA) and perfusion imaging using MS-325.
- Prepulse-optimized LGE imaging with MS-325 at multiple time points, compared to Gd-DTPA.
Main Results:
- MS-325 successfully detected LGE in all patients at all time points.
- Optimal accuracy was achieved 54 ± 4 minutes post-injection.
- Sensitivity was 84% and specificity was 98% when compared to Gd-DTPA.
Conclusions:
- Intravascular MS-325 demonstrates potential for visualizing chronic MI.
- MS-325 showed a smaller transmural extent and fewer involved segments compared to Gd-DTPA.
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