Related Experiment Videos
Osteosarcoma: correlation between radiological and histological changes after intra-arterial chemotherapy
J I Bilbao1, S Martín Algarra, J Martínez de Negri
1Department of Radiology, Clínica Universitaria de Navarra, Pamplona, Spain.
European Journal of Radiology
|September 1, 1990
Summary
Angiography effectively correlates with tumor necrosis in osteosarcoma patients, aiding in treatment evaluation. This radiological method helps assess neoadjuvant chemotherapy effectiveness in osteosarcoma (OS) patients.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Osteosarcoma (OS) treatment involves multidisciplinary approaches.
- Evaluating tumor necrosis (TN) is crucial for treatment efficacy.
- Radiological methods are used to assess treatment response.
Purpose of the Study:
- To statistically correlate radiological methods with tumor necrosis in osteosarcoma.
- To identify reliable radiological signs for assessing treatment response.
- To evaluate the efficacy of neoadjuvant chemotherapy in osteosarcoma.
Main Methods:
- Studied 31 osteosarcoma patients treated with neoadjuvant chemotherapy and surgery.
- Compared conventional radiography, computed tomography, and angiography with resected tumor necrosis.
- Analyzed specific radiological signs including tumoral stain, neovascularity, and peritumoral fat planes.
Main Results:
- Angiography showed a significant correlation with tumor necrosis (p = 0.02).
- Specific signs 'tumoral stain and neovascularity' (p = 0.02) and 'peritumoral fat planes' (p = 0.05) correlated with TN.
- Conventional radiography and computed tomography did not show significant correlation with TN.
Conclusions:
- Angiography is a valuable tool for preoperative evaluation of tumor necrosis in osteosarcoma.
- Angiography can effectively define the efficacy of neoadjuvant chemotherapy in osteosarcoma.
- Specific radiological signs observed on angiography aid in assessing treatment response.