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Efficacy and safety of propiverine in children with overactive bladder

Woo Jung Kim1, Dong-Gi Lee, Sang Wook Lee

  • 1Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Korean Journal of Urology
|April 27, 2012
PubMed

Insights

Propiverine effectively treats overactive bladder (OAB) in children, improving bladder capacity and reducing voiding frequency. This antimuscarinic medication is safe and well-tolerated for pediatric OAB patients, with or without incontinence.

Area of Science:

  • Pediatric Urology
  • Pharmacology
  • Clinical Medicine

Background:

  • Antimuscarinic therapy is a common treatment for pediatric overactive bladder (OAB).
  • Limited clinical data exists on the outcomes of antimuscarinic use in children with OAB.
  • Propiverine is frequently prescribed for pediatric OAB.

Purpose of the Study:

  • To evaluate the efficacy and safety of propiverine in treating pediatric overactive bladder (OAB).
  • To compare treatment outcomes in children with and without urge incontinence (UI).

Main Methods:

  • Retrospective review of 68 children with OAB treated with propiverine over 5 years.
  • Comparison of response rates between non-urge incontinence (non-UI) and urge incontinence (UI) groups.
  • Analysis of cumulative response rates by treatment duration.

Main Results:

  • Overall response rate was 86.8%.
  • Functional bladder capacity increased from 140 ml to 150 ml; daily voiding frequency decreased from 14.0 to 8.5.
  • No significant difference in response rates between non-UI (88.0%) and UI (83.3%) groups. Adverse effects were minimal (2.9%) and not severe.

Conclusions:

  • Propiverine demonstrates efficacy in treating pediatric OAB, regardless of the presence of UI.
  • The medication is well-tolerated in the pediatric population.
  • Propiverine offers a safe and effective treatment option for children with OAB.
Abstract

Keywords:
ChildrenIncontinenceOveractive bladderPropiverine

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