Related Experiment Video
Updated: May 22, 2026
04:09
Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film
Published on: December 13, 2024
Stability testing of alginate-chitosan films
Miloslava Rabisková1, Katerina Dvorácková, Lenka Kofronvá
1Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, 612 42 Brno. rabiskovam@vfu.cz
Summary
Rutin pellets coated with sodium alginate-chitosan film demonstrated excellent stability. The film maintained drug dissolution profiles under various storage conditions, indicating a promising pharmaceutical formulation.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Rutin, a flavonoid, possesses various therapeutic properties.
- Developing stable oral drug delivery systems is crucial for effective rutin therapy.
Purpose of the Study:
- To evaluate the stability and dissolution characteristics of rutin-loaded pellets coated with sodium alginate-chitosan film.
- To assess the impact of storage conditions on the integrity of the coated film.
Main Methods:
- Pellets containing rutin were prepared using extrusion/spheronization.
- Coating was performed with a sodium alginate-chitosan film.
- Dissolution profiles were evaluated across a range of gastrointestinal pH conditions.
- Stability testing was conducted under accelerated conditions (25°C/60% RH, 30°C/65% RH, 40°C/75% RH) for up to 12 months.
- Similarity factors were used to compare dissolution profiles before and after storage.
Main Results:
- The sodium alginate-chitosan film exhibited excellent stability.
- Dissolution profiles remained consistent with original profiles after storage.
- Similarity factor values consistently exceeded 50, indicating minimal changes in drug release.
Conclusions:
- The sodium alginate-chitosan coating provides a stable and effective film for rutin-loaded pellets.
- This formulation demonstrates good potential for oral drug delivery, maintaining drug release characteristics under various storage conditions.
