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TNF-α expression in the UCB-MSCs as stable source inhibits gastric cancers growth in nude mice
Weizheng Mao1, Xinhong Zhu, Dongqi Tang
1Department of General Surgery, Qingdao Municipal Hospital, Qingdao, China.
Abstract:
Mesenchymal stem cells (MSCs) are potentially vehicles for therapy of malignant diseases. In our study, we investigated whether UCB-MSCs are capable to carry TNF-α to target tumor cells in vivo. The human gastric cancer cells SGC-7901 were subcutaneously injected into the abdomen near groins of 15 nude mice to establish experiment tumor models. MSC-TNF-α demonstrated a strong suppressive effect on the tumor growth compared with MSC and NaCl. Thus, MSC-TNF-α can obviously inhibit Gastric cancers growth in nude mice, indicating that UCB-MSCs may have the potential to become a prevention approach against gastric cancer.
Insights
Umbilical cord mesenchymal stem cells (UC-MSCs) engineered to carry tumor necrosis factor-alpha (TNF-α) effectively inhibited gastric cancer growth in mice. This suggests UC-MSCs hold promise as a novel cancer therapy delivery system.
Area of Science:
- Oncology
- Stem Cell Biology
- Biomedical Engineering
Background:
- Mesenchymal stem cells (MSCs) show potential for treating malignant diseases.
- Investigating the therapeutic capabilities of MSCs for targeted cancer treatment is crucial.
Purpose of the Study:
- To evaluate the efficacy of umbilical cord-derived MSCs (UC-MSCs) engineered to deliver tumor necrosis factor-alpha (TNF-α) in inhibiting gastric cancer growth in vivo.
- To determine if UC-MSCs can serve as effective carriers for therapeutic agents against gastric cancer.
Main Methods:
- Established human gastric cancer xenograft models in nude mice by subcutaneously injecting SGC-7901 cells.
- Administered UC-MSCs engineered to express TNF-α (MSC-TNF-α) to the tumor-bearing mice.
- Compared the tumor growth in mice treated with MSC-TNF-α, unmodified MSCs, and a saline control (NaCl).
Main Results:
- MSC-TNF-α treatment demonstrated a significant suppressive effect on gastric tumor growth compared to control groups.
- Unmodified MSCs and NaCl showed no significant impact on tumor progression.
- The study observed a clear inhibition of gastric cancer growth in vivo following MSC-TNF-α administration.
Conclusions:
- Engineered UC-MSCs carrying TNF-α effectively inhibit gastric cancer growth in a mouse model.
- UC-MSCs represent a promising cell-based delivery platform for cancer therapeutics.
- This approach indicates a potential for UC-MSCs in the prevention and treatment strategies for gastric cancer.
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