Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Two new cases of fragile X syndrome without CGG triplet expansion. Clinical-molecular characterization and review of the literature.

European journal of medical genetics·2026

Same author

Longitudinal Transcriptomic Analysis Reveals Systemic Effects of Risdiplam in Adults with Spinal Muscular Atrophy.

Brain sciences·2026

Same author

Supramolecular Deep Eutectic Solvents as a Janus Green Platform: Integrating Curcuminoid Extraction and Biopolymer.

Molecules (Basel, Switzerland)·2026

Same author

Dual actionability of BMI1 activation and mitotic vulnerability defines adaptive Osimertinib resistance in EGFR-mutant NSCLC.

Cell death & disease·2026

Same author

Feature representation for explainable CRISPR off-target prediction and base editing efficiency.

Frontiers in bioinformatics·2026

Same author

Evaluation of Anti-dsDNA Antibodies in Laboratory Practice: Management of Different Analytical Methods and Correlation with HEp-2 Immunofluorescence Patterns.

Antibodies (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: May 22, 2026

Fluorescence-microscopy Screening and Next-generation Sequencing: Useful Tools for the Identification of Genes Involved in Organelle Integrity

Fluorescence-microscopy Screening and Next-generation Sequencing: Useful Tools for the Identification of Genes Involved in Organelle Integrity

Published on: April 13, 2012

BEAT: Bioinformatics Exon Array Tool to store, analyze and visualize Affymetrix GeneChip Human Exon Array data from

Arianna Consiglio¹, Massimo Carella, Giorgio De Caro

¹Institute for Biomedical Technologies of Bari - ITB, National Research Council, Bari, 70126, Italy.

BMC Bioinformatics

|April 28, 2012

Summary

Alternative splicing (AS) is crucial for gene expression and disease. BEAT is a new bioinformatics tool that analyzes exon array data, offering insights into AS events in human diseases without requiring programming knowledge.

More Related Videos

A Rapid High-throughput Method for Mapping Ribonucleoproteins (RNPs) on Human pre-mRNA

A Rapid High-throughput Method for Mapping Ribonucleoproteins (RNPs) on Human pre-mRNA

Published on: December 2, 2009

Global Gene Expression Analysis Using a Zebrafish Oligonucleotide Microarray Platform

Global Gene Expression Analysis Using a Zebrafish Oligonucleotide Microarray Platform

Published on: August 10, 2009

Related Experiment Videos

Last Updated: May 22, 2026

Fluorescence-microscopy Screening and Next-generation Sequencing: Useful Tools for the Identification of Genes Involved in Organelle Integrity

Fluorescence-microscopy Screening and Next-generation Sequencing: Useful Tools for the Identification of Genes Involved in Organelle Integrity

Published on: April 13, 2012

A Rapid High-throughput Method for Mapping Ribonucleoproteins (RNPs) on Human pre-mRNA

A Rapid High-throughput Method for Mapping Ribonucleoproteins (RNPs) on Human pre-mRNA

Published on: December 2, 2009

Global Gene Expression Analysis Using a Zebrafish Oligonucleotide Microarray Platform

Global Gene Expression Analysis Using a Zebrafish Oligonucleotide Microarray Platform

Published on: August 10, 2009

Area of Science:

Genomics
Bioinformatics
Molecular Biology

Background:

Alternative splicing (AS) generates transcript diversity from single genes, impacting cellular differentiation and disease.
Exon array technology provides detailed gene expression profiles, enabling analysis at both gene and exon levels.
Existing analysis tools often lack advanced statistical features or require programming expertise.

Purpose of the Study:

To introduce BEAT, an integrated, user-friendly bioinformatics framework for storing, analyzing, and visualizing exon array datasets.
To provide a platform for comprehensive study of AS events in human diseases.
To offer advanced statistical features for AS analysis without programming knowledge.

Main Methods:

Development of BEAT, a web-based bioinformatics framework combining a data warehouse approach with statistical methods.
Integration of exon and gene level expression plots with annotations (alternative names, IDs, Gene Ontology, pathways).
Implementation of meta-statistics for novel exploration of analysis results and multivariate AS analysis using clinical data.

Main Results:

BEAT is a web tool with a graphical front-end for uploading and analyzing exon array data.
The tool was tested on 173 samples and refined with colorectal and renal cell cancer datasets.
BEAT displays analysis results through interactive tables and graphics, customizable with user-defined thresholds.

Conclusions:

BEAT addresses the need for user-friendly, statistically advanced tools for exon array data analysis.
The platform facilitates comprehensive studies of alternative splicing in human diseases.
BEAT enhances the interpretation of AS events through interactive visualizations and customizable analyses.