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Selective cannabinoid receptor 2 modulators: a patent review 2009--present
1Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, D-88397 Biberach an der Riss, Germany. Doris.riether@boehringer-ingelheim.com
Expert Opinion on Therapeutic Patents
|April 28, 2012
Summary
Selective cannabinoid receptor 2 (CB2) modulators show promise for pain therapy, with numerous compounds identified and undergoing clinical trials. Continued research into CB2 receptor modulation is anticipated to yield new therapeutic drugs.
Area of Science:
- Immunology
- Pharmacology
- Neuroscience
Background:
- Cannabinoid receptor 2 (CB2) activation influences immune responses, including inflammation and neuroprotection, and exhibits analgesic properties.
- Research focuses on selective CB2 modulators to avoid CB1-mediated psychotropic effects.
Purpose of the Study:
- To review patent literature on CB2 selective modulators published since April 2009.
- To summarize CB2 biology, therapeutic potential, and development status of selective CB2 agonists.
Main Methods:
- Review of patent literature on CB2 selective modulators.
- Summary of CB2 receptor biology and drug development.
Main Results:
- Identification of numerous highly selective CB2 modulators across various chemotypes.
- Demonstration of analgesic effects in animal models, supporting CB2 as a pain therapy target.
Conclusions:
- Sustained interest in CB2 receptor as a drug target.
- Clinical trials initiated, though some terminated, indicating ongoing development.
- Anticipation of new CB2-modulating drugs with improved understanding of cannabinoid receptors.
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