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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa

P E J Van Der Meijden1, M Van Schilfgaarde, R Van Oerle

  • 1Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.

Journal of Thrombosis and Haemostasis : JTH
|April 28, 2012
PubMed
Summary

Microparticles (MPs) from platelets and erythrocytes initiate blood clotting via factor XII (FXII), independent of tissue factor (TF). Monocyte-derived MPs primarily use TF to trigger coagulation.

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