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Updated: May 22, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

Speckle tracking-derived mitral annular velocities predict mortality in patients with acute coronary syndrome

Sirikarn Napan1, Thaslim A Kassim, Shubhada Kumar

  • 1Division of Cardiology, Howard University Hospital, Washington, District of Columbia 20060, USA. snapan@howard.edu

Echocardiography (Mount Kisco, N.Y.)
|April 28, 2012
PubMed

Insights

Speckle tracking echocardiography (STE) can measure mitral annular velocities to predict mortality in patients with acute coronary syndrome (ACS). Higher E/E' ratios indicate increased mortality risk, with a ratio over 30 being a significant predictor.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Physiology

Background:

  • Myocardial ischemia impairs relaxation, increasing left ventricular diastolic pressure.
  • Mitral annular velocities are noninvasive markers for diastolic pressure.
  • Speckle tracking echocardiography (STE) offers novel methods for assessing these velocities.

Purpose of the Study:

  • To evaluate if mitral annular velocities measured by STE can predict mortality in patients with acute coronary syndrome (ACS).

Main Methods:

  • Retrospective study of 246 ACS patients.
  • STE analysis of mitral annular velocities (E' and A') from four regions.
  • Measurement of peak early diastolic mitral inflow velocity (E) using pulsed-wave Doppler.

Main Results:

  • Lower E', lower A', higher E'/A', and higher E/E' ratios were independently associated with increased mortality risk.
  • An E/E' ratio > 30 predicted death in univariate and multivariate analyses (adjusted HR, 1.91).

Conclusions:

  • Mitral annular velocities measured by STE are predictive of mortality in ACS patients.
Abstract

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