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Infectious keratitis in severe limbal stem cell deficiency: characteristics and risk factors

Otman Sandali1, Thomas Gaujoux, Pablo Goldschmidt

  • 1Centre Hospitalier National d'Ophtalmologie des XV-XX, Pierre & Marie Curie University Paris 06, Research team 968, Institut de la Vision, Paris, France. sanotman1@yahoo.fr

Ocular Immunology and Inflammation
|April 28, 2012
PubMed
Abstract

Insights

Infectious keratitis is common and severe in patients with limbal stem cell deficiency (LSCD). Preventing epithelial defects and using therapeutic contact lenses cautiously can reduce infection risk.

Area of Science:

  • Ophthalmology
  • Microbiology

Background:

  • Limbal stem cell deficiency (LSCD) can compromise corneal health.
  • Infectious keratitis poses a significant threat to vision in LSCD patients.

Purpose of the Study:

  • To determine the incidence, clinical features, and microbiological causes of infectious keratitis in LSCD.
  • To identify risk factors associated with infectious keratitis in this patient population.

Main Methods:

  • Retrospective comparative case series analysis.
  • Involved 35 patients with severe LSCD.
  • Mean follow-up of 46 months.

Main Results:

  • Gram-positive bacteria were the primary cause (94%) of infections.
  • Treatment often required amniotic membrane transplantation (42%) or keratoplasty (21%).
  • Risk factors included contact lens wear, epithelial defects, corneal vascularization, and immunosuppressive eye drops.

Conclusions:

  • Infectious keratitis is a frequent and severe complication in LSCD.
  • Restoring epithelial integrity and judicious use of therapeutic contact lenses are key preventive strategies.

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