[Condition of cell membranes in simulated motion sickness and use of alpha-tocopherol]

The purpose of the work was to study the mechanism responsible for adaptive reorganization of membranes--lipid peroxidation during simulated motion sickness (MS) in animals. It was shown that during MS rats exhibited an elevation of the level of diene conjugates and Schiff foundations in the brain indicating lipid peroxidation activation. A similar increase of phospholipase A2 activity in the brain was noted. In the liver, myocardium and erythrocytes the above changes were insignificant. An antioxidant beta-tocopherol inhibited lipid peroxidation in the rat brain and possessed the vestibule-protective effect in cats that was presumably related to its membrane-stabilizing action.