[The effect of the complex platinum (IV) compound oxoplatinum on the immune system]

The effect of a Pt (IV) complex compound--oxoplatinum on the humoral and cell immunity in mice was studied. It was established that the drug produced dose-dependent inhibition of T-dependent humoral response to ram erythrocytes. Oxoplatinum appeared to be a costimulator of a mitogen phytohemagglutinin in lymphocyte proliferation slightly influencing allogen-induced proliferation. The stimulation of T-lymphocyte cytotoxicity by small doses of oxoplatinum was also found.