Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 22, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Forensic identification using a multiplex assay of 47 SNPs.

Yi-Liang Wei1, Cai-Xia Li, Jing Jia

  • 1Key Laboratory of Ministry of Public Health for Forensic Science, Department of Forensic Science, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.

Journal of Forensic Sciences
|April 28, 2012
PubMed
Summary

A new panel of 47 single nucleotide polymorphisms (SNPs) offers a powerful DNA profiling alternative. This SNP analysis is effective for individual identification, especially with degraded DNA samples, matching STR profiling capabilities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-thrombectomy angiography-derived fractional flow is associated with functional outcomes in ICAS-related large vessel occlusion.

Journal of neurointerventional surgery·2026
Same author

Endovascular treatment and outcome in patients with CTP-defined extra-large infarct core stroke.

Journal of neurointerventional surgery·2026
Same author

SNP density impact on kinship inference and IBS-machine learning optimization.

Yi chuan = Hereditas·2026
Same author

Overexpression of PcNAC2 from Poa crymophila significantly enhances plant tolerance to chilling, salinity and osmotic stresses.

BMC plant biology·2025
Same author

Effect of Sema3F on VEGF in Primary Rat Hippocampal Neurons In vitro.

Current molecular medicine·2025
Same author

Titanium ions promote tomato growth and increase stress resistance.

BMC plant biology·2025

Area of Science:

  • Forensic Genetics
  • Molecular Biology
  • Human Identification

Background:

  • Short tandem repeat (STR) profiling is a standard method for DNA analysis.
  • Degraded DNA samples can pose challenges for traditional STR profiling.
  • Single nucleotide polymorphisms (SNPs) offer an alternative marker system for DNA analysis.

Purpose of the Study:

  • To develop and validate a novel panel of 47 single nucleotide polymorphisms (SNPs) for DNA profiling and ABO genotyping.
  • To evaluate the efficacy of SNP analysis as an alternative to STR profiling, particularly for degraded DNA.
  • To assess the performance of the SNP panel in historical forensic cases.

Main Methods:

  • Selection of 42 validated universal individual identification SNPs and five additional SNPs (one gender, four ABO loci).

More Related Videos

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence
11:49

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Published on: March 9, 2015

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

Related Experiment Videos

Last Updated: May 22, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence
11:49

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Published on: March 9, 2015

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

  • Genotyping using the SNPstream® platform.
  • Analysis of match probability in Han Chinese population and assessment in historical paternity and individual identification cases.
  • Comparison of SNP profiling with STR profiling on degraded DNA samples.

    • Main Results:

    • The 42 validated SNPs achieved a match probability of 9.5 × 10(-18) in Han Chinese.
    • SNP analysis successfully resolved historical paternity and individual identification cases.
    • SNPstream® genotyping identified all 47 SNPs from degraded DNA, whereas STR profiling yielded limited data.

    Conclusions:

    • The novel 47-SNP panel is effective for DNA profiling and ABO genotyping.
    • SNP analysis demonstrates comparable effectiveness to STR profiling for human identification.
    • SNP analysis is particularly advantageous for individual identification when dealing with degraded DNA samples.