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Evaluation of meningococcal serogroup C conjugate vaccine programs in Canadian children: interim analysis

Julie A Bettinger1, David W Scheifele, Scott A Halperin

  • 1Vaccine Evaluation Center, BC Children's Hospital, Vancouver, Canada. jbettinger@cw.bc.ca

Vaccine
|April 28, 2012
PubMed

Insights

Two meningococcal C (MenC) vaccine doses in infancy provide optimal protection. Even one dose at two months offers substantial protection against MenC disease.

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatrics

Background:

  • Assessing antibody titers from meningococcal C- (MenC) tetanus toxoid conjugate vaccine.
  • Evaluating vaccine efficacy across different infant immunization schedules.

Purpose of the Study:

  • To determine the antibody titers afforded by the MenC-tetanus toxoid conjugate vaccine.
  • To compare the immunogenicity of 1-dose, 2-dose, and 3-dose MenC infant immunization schedules at 12 months of age.

Main Methods:

  • Prospective study of three infant cohorts on different MenC immunization programs.
  • Serum bactericidal activity (SBA) titers were measured before and after the 12-month vaccination dose.
  • Protective SBA titers were defined as ≥ 1:8.

Main Results:

  • Prior doses significantly impacted protective titers before the 12-month dose.
  • 100% protection in infants with 2 prior doses vs. 84.0% with 1 dose and 27.6% with no prior doses.
  • All infants achieved protective titers post-vaccination, with higher titers following priming.

Conclusions:

  • Two MenC vaccine doses in infancy provide optimal protection during the first year.
  • One dose at 2 months of age offers substantial protection.
  • Infant immunization schedules influence vaccine immunogenicity and protective antibody levels.
Abstract

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