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Updated: May 22, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Coronary artery bypass grafting after percutaneous coronary intervention
Syed Shahabuddin1, Syed Ahmed Sami, Junaid Alam Ansari
1Department of Surgery, The Aga Khan University Hospital, Karachi. syed.shahab@aku.edu
Insights
Patients needing coronary artery bypass grafting (CABG) after percutaneous intervention (PCI) often have complex coronary artery disease. Restenosis and disease progression were key reasons for subsequent surgical revascularization in this study.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Cardiac Surgery
Background:
- Percutaneous intervention (PCI) is a common treatment for coronary artery disease (CAD).
- Restenosis, disease progression, and multi-vessel involvement after PCI can necessitate further intervention.
- Coronary artery bypass grafting (CABG) is a surgical option for complex CAD cases.
Purpose of the Study:
- To evaluate patients who underwent CABG after previous PCI.
- To identify the primary reasons for requiring surgical revascularization post-PCI.
- To analyze the characteristics and risk factors of patients needing repeat revascularization.
Main Methods:
- Retrospective analysis of 610 patients undergoing CABG over 12 months.
- Identification of 34 patients with prior PCI/stenting.
- Assessment of coronary risk factors, disease extent, and reasons for reintervention.
Main Results:
- 34 out of 610 patients (5.6%) had undergone prior PCI/stenting.
- High prevalence of risk factors: hypertension (85%), diabetes mellitus (60%), dyslipidemia (60%), tobacco use (50%), family history (53%).
- Multi-vessel disease (67%) and stent stenosis were primary drivers for reintervention.
Conclusions:
- Restenosis and disease progression following PCI are significant reasons for subsequent CABG.
- Patients requiring revascularization often present with multiple cardiovascular risk factors.
- Careful patient selection is crucial for optimizing outcomes with either PCI or CABG in complex CAD.
Abstract:
Following percutaneous intervention (PCI), restenosis, progression of disease and multi-vessel involvement may require further intervention in the form of surgical revascularization. Patients with coronary artery bypass grafting (CABG) done after PCI were evaluated to find out the reason for the need of surgical revascularization. Over a period of 12 months, 610 patients underwent CABG. Out of them, 34 patients had previous PCI/stenting. Coronary risk factors including hypertension in 85%, diabetes mellitus in 60%, dyslipidemia in 60%, tobacco use in 50% and a positive family history was present in 53% of the patients. All patients were symptomatic. Multi-vessel disease was present in 67% and single vessel in 4.7%. The extent of disease and stenosis of stents were responsible for reintervention. Careful selection of patients is required in presence of multiple risk factors for coronary artery disease to provide maximum benefit by either PCI or CABG.
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