Morphogenesis of cerebral matrix ectopies in human fetus and newborn

The subject of investigations was genesis of periventricular, cerebral matrix ectopies in human fetuses and newborns. The morphologic and histochemical analysis concerned the embryonal elements of the ventricular wall: namely neuroepithelium with membrana limitans externa and suporficial layer of the germinal matrix. It has been distinguished four stages in the development of ectopic changes: 1) atrophy of neuroepithelium, 2) superficial necrobiosis with disruption of membrana limitans externa, 3) egsophytic neuroglial ectopies with organization or sequestration within the ventricular light, 4) neuroeptithelial inclusions in the periventricular zone. The disclosed, destructive changes in superficial layers of the germinal matrix as well as their glial organization suggested that reparative processes that could be an evidence of the passed perinatal hypoxia occur in the ventricular light.