Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A dual-stream temporal attention LSTM with visual feature enhancement for depression screening in incarcerated populations.

Frontiers in psychology·2026
Same author

Response mechanisms of enhanced biological phosphorus removal systems to microplastics stress.

Journal of hazardous materials·2026
Same author

Leveraging formate toxicity for simultaneous nitrate removal and in-situ sludge reduction in AnMBR: mechanisms of metabolic uncoupling and cryptic growth.

Bioresource technology·2026
Same author

Metagenomic profiling of resistome and mobilome dynamics in diverse freshwater aquaculture modes.

Water research·2026
Same author

A Neural Network-Enhanced Kalman Filter for Time Series Anomaly Detection in Cyber-Physical Systems.

Sensors (Basel, Switzerland)·2026
Same author

Understand systemic risk from mangrove ecosystem through network analysis.

Fundamental research·2026

Related Experiment Video

Updated: May 22, 2026

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
07:28

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity

Published on: January 21, 2017

Frequency-domain EEG source analysis for acute tonic cold pain perception.

Shiyun Shao1, Kaiquan Shen, Ke Yu

  • 1Department of Mechanical Engineering, National University of Singapore, Singapore.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|April 28, 2012
PubMed
Summary

This study used electroencephalogram (EEG) source analysis to find brain activity patterns related to tonic cold pain. Specific brain oscillations in the prefrontal and cingulate regions correlated with pain intensity, offering objective pain measures.

More Related Videos

The Combination of Transcranial Alternating Current Stimulation and Electroencephalogram
06:14

The Combination of Transcranial Alternating Current Stimulation and Electroencephalogram

Published on: October 10, 2025

Understanding the Effects of Non-Invasive Transauricular Vagus Nerve Stimulation on EEG and HRV
04:59

Understanding the Effects of Non-Invasive Transauricular Vagus Nerve Stimulation on EEG and HRV

Published on: January 19, 2024

Related Experiment Videos

Last Updated: May 22, 2026

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
07:28

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity

Published on: January 21, 2017

The Combination of Transcranial Alternating Current Stimulation and Electroencephalogram
06:14

The Combination of Transcranial Alternating Current Stimulation and Electroencephalogram

Published on: October 10, 2025

Understanding the Effects of Non-Invasive Transauricular Vagus Nerve Stimulation on EEG and HRV
04:59

Understanding the Effects of Non-Invasive Transauricular Vagus Nerve Stimulation on EEG and HRV

Published on: January 19, 2024

Area of Science:

  • Neuroscience
  • Pain Research
  • Electrophysiology

Background:

  • Tonic cold pain perception involves complex neural processing.
  • Objective measures for acute pain assessment are needed.
  • Electrocortical activity, particularly in specific frequency bands, may serve as pain biomarkers.

Purpose of the Study:

  • To investigate electrocortical responses to tonic cold pain using frequency-domain electroencephalogram (EEG) source analysis.
  • To identify potential electrocortical indices of acute tonic pain.

Main Methods:

  • Scalp EEG data were recorded from 26 healthy subjects under tonic cold pain (CP) and no-pain control (NP) conditions.
  • Standardized low-resolution brain electromagnetic tomography (sLORETA) was used for EEG source localization.
  • EEG power spectra and source power were compared across five frequency bands (1-4 Hz, 4-8 Hz, 8-12 Hz, 12-18 Hz, 18-30 Hz).

Main Results:

  • Significant differences in source power between CP and NP conditions were observed in the 8-12 Hz (CPNP) bands across extensive brain regions.
  • Significant differences in 4-8 Hz and 12-18 Hz source activities were also found.
  • Left medial frontal, left superior frontal, anterior cingulate, and posterior cingulate activities in specific frequency bands negatively correlated with subjective pain ratings.

Conclusions:

  • Tonic cold pain perception is associated with cortical source power changes across multiple frequency bands and brain regions.
  • Oscillatory activities in the prefrontal and cingulate regions correlate with subjective pain intensity.
  • These findings suggest potential objective measures for pain assessment and targets for pain treatment through neural oscillation modulation.