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Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties
Colin L Walsh1, Juliane Nguyen, Francis C Szoka
1The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA 94720-1762, USA.
Abstract:
We report the synthesis and biophysical characterization of a novel class of zwitterionic lipids (ZL) with head groups containing a 3° or 4° amine and carboxylate. ZL form stable liposomes that exhibit head group dependent, pH-responsive biophysical characteristics. These lipids may be suitable components for drug delivery applications due to their ease of synthesis and unique pH-dependent properties.
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