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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Related Experiment Video

Updated: May 22, 2026

Performing Repeated Intraoperative Impedance Telemetry Measurements during Cochlear Implantation
06:54

Performing Repeated Intraoperative Impedance Telemetry Measurements during Cochlear Implantation

Published on: August 4, 2023

Cochlear implant performance in geriatric patients.

Minoo Lenarz1, Hasibe Sönmez, Gert Joseph

  • 1Department of Otolaryngology/Head and Neck Surgery, Charité, Medical University of Berlin, Berlin, Germany. minoo.lenarz@Charite.de

The Laryngoscope
|April 28, 2012
PubMed
Summary
This summary is machine-generated.

Older adults (70+) receiving cochlear implants (CIs) show similar hearing gains as younger adults, especially in quiet environments. However, their performance significantly declines in noisy conditions, suggesting a need for tailored rehabilitation.

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Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages
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Last Updated: May 22, 2026

Performing Repeated Intraoperative Impedance Telemetry Measurements during Cochlear Implantation
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Published on: August 4, 2023

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages
06:04

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages

Published on: March 24, 2023

Area of Science:

  • Audiology
  • Gerontology
  • Neurosurgery

Background:

  • Cochlear implantation (CI) offers significant hearing restoration for adults with severe to profound hearing loss.
  • The efficacy of CI in geriatric populations (70+ years) compared to younger adults requires further investigation.

Purpose of the Study:

  • To evaluate and compare hearing performance in geriatric CI patients (70+) versus younger adult CI recipients.
  • To assess the learning curve and speech perception abilities in quiet and noisy environments.

Main Methods:

  • Retrospective cohort study of 1,005 postlingually deafened adults undergoing cochlear implantation.
  • Patients were stratified into four age groups: 18-39, 40-59, 60-69, and 70+ years.
  • Speech perception was evaluated using standard German speech tests (Freiburger Monosyllabic Test, Speech Tracking Test, HSM Test) in quiet and noise.

Main Results:

  • Geriatric CI patients demonstrated a comparable learning curve to younger adults within the first two years post-implantation.
  • No significant differences in speech perception were observed between geriatric and younger groups in quiet conditions.
  • Geriatric patients exhibited significantly lower speech perception performance in noise compared to younger adults.

Conclusions:

  • Geriatric CI recipients achieve similar hearing rehabilitation outcomes as younger adults in quiet settings.
  • Poorer performance in noise among older adults may be attributed to central presbycusis, necessitating adjusted postoperative fitting strategies.
  • Further research into specialized rehabilitation and cognitive training is recommended to enhance speech perception in noise for geriatric CI patients.