Related Experiment Video
Updated: May 22, 2026
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Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent
Published on: May 8, 2017
Impact of H-aggregation on activatable MMP-2-specific probes for optical imaging
Réjean Lebel1, Marc-André Bonin, Riadh Zriba
1Département de médecine nucléaire et de radiobiologie, Centre d'imagerie moléculaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
Contrast Media & Molecular Imaging
|April 28, 2012
Abstract:
In order to target and image MMP-2 activity using optical imaging, we developed a panel of new MMP-2 probes based on Cy5 and QSY21 as fluorophore/quencher FRET partners, separated by various MMP-2 specific peptide substrates. We compared these probes for their specificity against other MMPs, their rate of activation by MMP-2 and their initial quenching.
