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Updated: May 22, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Cellular host responses to gliomas.

Joseph Najbauer¹, Peter C Huszthy, Michael E Barish

¹Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America. jnajbauer@coh.org

|April 28, 2012

Summary

This summary is machine-generated.

Glioblastoma multiforme (GBM) recruits host nestin-expressing cells that form tumor vasculature with pericytes. Understanding this cellular crosstalk is key for developing new glioblastoma therapies.

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Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

Area of Science:

Neuroscience
Oncology
Cell Biology

Background:

Glioblastoma multiforme (GBM) is an aggressive brain tumor.
Understanding the tumor microenvironment is crucial for GBM pathology.
Previous studies advanced glioma biology but lacked cellular composition mapping.

Purpose of the Study:

To identify major cell populations attracted by glioma.
To map the cellular composition of the GBM tumor microenvironment.
To understand the crosstalk between glioma and host cells.

Main Methods:

Utilized orthotopic rodent models of human glioma xenografts.
Performed marker-specific, anatomical, and morphological analyses.
Investigated cellular origins and interactions within the tumor microenvironment.

Main Results:

Glioma xenografts recruited host nestin-expressing cells originating from the subventricular zone.
These cells formed networks with glioma, distinguished from pericytes.
Two GBM phenotypes were observed: invasive/non-angiogenic and angiogenic with distinct cellular morphologies.
Stromal cell-derived factor-1 and CXCR4 were highly expressed, suggesting roles in invasion.

Conclusions:

Host nestin-expressing cells and pericytes collaborate to form tumor vasculature.
Mapping glioma microenvironment cellular composition aids novel anti-glioma therapy development.
Deciphering tumor-host crosstalk is vital for future GBM treatment strategies.