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Updated: May 22, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Clinical differences between opioid abuse classes ameliorated after 1 year of buprenorphine-medication assisted
Joseph Tkacz1, Jamie Severt, Cheryl Kassed
1Health Analytics, LLC, Columbia, Maryland 21045, USA. joseph.tkacz@healthanalytic.com
Abstract:
This study compared the clinical and demographic profiles of three opioid-dependent user groups, and measured their response to 1 year of buprenorphine-medication assisted treatment. Opioid prescription, street, and combination (street + prescription) users completed the Addiction Severity Index multiple times over the course of one treatment year. Although groups differed on all measured demographics (P values <.05) and on six of seven Addiction Severity Index composite scores at induction (P values <.05), differences were ameliorated after 1 year. Findings highlight the disparities between the various opioid-dependent patient subpopulations and suggest that buprenorphine-medication assisted treatment is an effective treatment across user subtypes.
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