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Related Experiment Videos

Long term cardiopulmonary bypass without systemic heparinization.

K von Segesser1, M Turina

  • 1Clinic for Cardiovascular Surgery, University Hospital, Zürich, Switzerland.

The International Journal of Artificial Organs
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

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Long-term cardiopulmonary bypass without systemic heparinization using heparin-coated equipment improved hemostasis and hemodynamics. This approach reduced the need for blood transfusions and maintained better blood pressure during extended procedures.

Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Hematology

Background:

  • Systemic heparinization is standard for cardiopulmonary bypass (CPB).
  • Long-term CPB can lead to complications like bleeding and hemodilution.
  • Heparin-coated equipment offers a potential alternative to systemic anticoagulation.

Purpose of the Study:

  • To compare the efficacy of CPB using heparin-coated equipment without systemic heparinization versus standard CPB with systemic heparinization.
  • To evaluate hemostatic and hemodynamic parameters during extended CPB procedures.

Main Methods:

  • Eight open-chest canine experiments were conducted.
  • Comparison between CPB with heparin-coated equipment (no systemic heparin) and standard CPB (systemic heparin).

Related Experiment Videos

  • Perfusion duration, transfusion needs, hematocrit, free plasma hemoglobin, platelet levels, and mean aortic pressure were measured.

    • Main Results:

    • Perfusion duration was similar in both groups (21 hours).
    • The heparin-coated group required fewer blood transfusions and showed significantly lower free plasma hemoglobin and platelet drop.
    • Mean aortic pressure remained stable in the heparin-coated group, unlike the standard heparin group.

    Conclusions:

    • Heparin-coated equipment allows for long-term CPB without systemic heparinization.
    • This method improves hemostasis, reduces blood component usage, and maintains superior hemodynamics.
    • Offers a promising alternative for extended CPB procedures, minimizing anticoagulation-related risks.