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Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...

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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
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Published on: October 12, 2012

[Anticoagulation clinics, present situation and future perspectives].

Eugénia Cruz1, Manuel Campos

  • 1Serviço de Hematologia, Hospital de Santo António, Centro Hospitalar do Porto, Porto, Portugal; Basic and Clinical Research on Iron Biology Group (BCRIB), Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|May 1, 2012
PubMed
Summary

Oral anticoagulant therapy monitoring in Portugal shows similar quality between hospital anticoagulation clinics and primary care. New oral anticoagulants pose a challenge to traditional monitoring methods.

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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
07:08

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

Area of Science:

  • Pharmacology and Therapeutics
  • Clinical Laboratory Science
  • Public Health

Context:

  • Oral anticoagulant therapy (OAT) management involves various monitoring modalities, including hospital-based, primary care, private laboratories, and self-monitoring.
  • In Portugal, hospital anticoagulation clinics remain the predominant OAT monitoring method, with primary care monitoring emerging in recent years.
  • Anticoagulation clinics have historically optimized warfarin management through clinical and laboratory follow-up.

Purpose:

  • To evaluate the quality of oral anticoagulant therapy control in Portugal by assessing the proportion of International Normalized Ratios (INRs) within the therapeutic range.
  • To compare the quality of OAT monitoring between a hospital anticoagulation clinic and primary care settings.
  • To identify challenges posed by new oral anticoagulants (NOACs) that do not require laboratory monitoring.

Summary:

  • A 2011 study at Santo António Hospital's anticoagulation clinic found 71% of ambulatory patient INRs within the therapeutic range.
  • In the same year, primary care centers in Baixo Tâmega region reported similar INR control quality.
  • These findings suggest that primary care monitoring can achieve comparable quality to specialized anticoagulation clinics.

Impact:

  • The study highlights the comparable quality of OAT monitoring between hospital clinics and primary care in Portugal.
  • The advent of NOACs presents a significant challenge, questioning the future role of anticoagulation clinics in patient registration, risk assessment, and adherence monitoring.
  • Further research is needed to understand how anticoagulation clinics will adapt and contribute in the era of NOACs.